Inhibitor-Induced Shift-Downs in Escherichia coli
نویسندگان
چکیده
منابع مشابه
Actinobolin-induced filamentation in Escherichia coli.
The inhibition of protein synthesis has been reported to be one mechanism by which actinobolin inhibits the growth of mammalian and bacterial cells (L. L. Bennett, personal communication; D. E. Hunt and R. F. Pittillo, Can. J. Microbiol. 12:515, 1966). Recent observations have revealed that cells of Escherichia coli which have been grown in the presence of actinobolin become extremely elongated...
متن کاملTranscriptional response of Escherichia coli to temperature shift.
Temperature shift is often practiced in the cultivation of Escherichia coli to reduce undesired metabolite formation and to maximize synthesis of correctly folded heterologous protein. As the culture temperature is decreased below the optimal 37 degrees C, growth rate decreases and many physiological changes occur. In this study, we investigated the gene expression dynamics of E. coli on switch...
متن کاملFunctional motifs in Escherichia coli NC101
Escherichia coli (E. coli) bacteria can damage DNA of the gut lining cells and may encourage the development of colon cancer according to recent reports. Genetic switches are specific sequence motifs and many of them are drug targets. It is interesting to know motifs and their location in sequences. At the present study, Gibbs sampler algorithm was used in order to predict and find functional m...
متن کاملIdentification of DNA gyrase inhibitor (GyrI) in Escherichia coli.
DNA gyrase is an essential enzyme in DNA replication in Escherichia coli. It mediates the introduction of negative supercoils near oriC, removal of positive supercoils ahead of the growing DNA fork, and separation of the two daughter duplexes. In the course of purifying DNA gyrase from E. coli KL16, we found an 18-kDa protein that inhibited the supercoiling activity of DNA gyrase, and we coined...
متن کاملTranscriptional inhibitor of virulence factors in enteropathogenic Escherichia coli.
The type III secretion system (TTSS) is a key virulence mechanism of many important gram-negative bacterial pathogens. The TTSS is conserved among different bacterial pathogens, and mutations and deletions to the system significantly decrease virulence, making the TTSS an important potential therapeutic target. We have developed a high-throughput assay to search for inhibitors of the TTSS. We s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1969
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.100.2.956-961.1969